Marcus Henderson is an American musician and video game designer, primarily known as the co-creator of the celebrated music video game series *Guitar Hero*. As the lead guitarist for the original Harmonix development team, he recorded the guitar covers for most of the tracks in the first installments of the series, defining its characteristic sound and helping to make them iconic. His career is inextricably linked to innovation in the field of rhythm games. Following the immense success of *Guitar Hero*, he continued to explore the intersection of music and technology, co-founding studios specializing in interactive musical experiences, such as Riff VR. For his revolutionary impact on the entertainment industry and popular culture, Henderson has received numerous accolades. The most prestigious was his inclusion, in 2008, on *Time* magazine's list of the 100 most influential people in the world, alongside business partner Alex Rigopulos.