Yûsuke Iseya (伊勢谷友介, born 1976) is a Japanese actor and director, renowned for his magnetic presence and his portrayal of complex and often ambiguous characters.

His film career includes memorable roles in works by prominent directors. Notable among his most significant performances is that of the charismatic Koga Gunbei in Takashi Miike's *13 Assassins* (2010), which solidified his reputation. He gained further popularity by portraying the iconic antagonist Shishio Makoto in the *Rurouni Kenshin* live-action trilogy (2014), a role that highlighted his ability to imbue even dark characters with charisma.

Iseya has also appeared in films such as *Sukiyaki Western Django* (2007) and *Thermae Romae* (2012), demonstrating versatility across various genres. His acting style is characterized by a controlled intensity and an ability to infuse emotional depth into even the most enigmatic roles.